Shaklee scientists went beyond resveratrol in the creation of Vivix by creating a unique and patent pending polyphenol blend that adds to the power of resveratrol. While resveratrol addresses 3 of 4 of the key mechanisms of aging, it is not very effective in addressing the formation of AGE proteins which can compromise cellular integrity and longevity. So Shaklee scientists identified and created a proprietary Rejuvetrol™ polyphenol blend that has been shown to be 10X more powerful than resveratrol alone at addressing this 4th mechanism of cellular aging.
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So, to help review the science supporting Vivix claims, we’ve included the citations of key studies that have been used to validate and support the most important claims we make, including:
Helps protect and repair cellular DNA (citations)
1. Usha, S., Irudayam, M.J., Malathi, R., “Interaction of Resveratrol and Genistein with Nucleic Acids”, Journal of Biochemistry and Molecular Biology, Vol 38, No. 2, March 2005, pp. 198-205
2. Niture, S., Velu, C., Smith, Q, Bhat, J., Srivenugopal, K, “Increased Expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventive natural products in human lymphocytes and tumor lines,” Carcinogenesis, Vol 28, no. 2, pp 378-389, 2007
3. Yang, S., Irani, K., Heffron, S., Jurnack, F., Meyskens, F., “Alterations in the expressions of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor” Molecular Cancer Therapeutics, 4(12), December 2005
4. Zahid, M., Gaikwad, N.W., Rogan, E.G., Cavalieri, E.L., “Inhibition of depurinating estrogen-DNA adduct formation by natural compounds,” Chemical Research in Toxicology, 20 (12): 1947-53, December 2007
5. Chakraborty S, Roy, M, Bhattacharya RK, “Prevention and repair of DNA damage by selected phytochemicals as measured by single cell gel electrophoresis,” Environmental Pathology, Toxicology, and Oncology, 2004; 23(3): 215-26
6. Gatz SA, Keimling M, Baumann C, Dörk T, Debatin KM, Fulda S, Wiesmüller L, “Resveratrol modulates DNA doublestrand break repair pathways in an ATM/ATR-p53- and –Nbs1-dependent manner” Carcinogenesis, 2008 Mar; 29 (3):51927. Epub 2008 Jan 3.
Positively impacts genetic regulators (citations)
1. Pearson, K., Baur, J., Lewis, K., Peshkin, L. et al., “Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span,” Cell Metabolism, 2008
2. Barger J.L., Kayo, T., Pugh, T.D., Prolla, T.A., Weindruch, R., “Short term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart,” Experimental Gerontology (2008), doi: 10.1016/j.exger.2008.06.013
3. Barger, J., Kayo, T., Vann, J., Arias, E., Wang, J., Hacker, T., Raederstorff, D., Morrow, J., Leeuwenburgh, C., Allison, D.,Saupe, K., Cartee, G., Weindruch, R., Prolla, T., “A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice,” PLoS ONE, 3(6): e2264, doi:10.1371/journal.pone.0002264
4. Howitz, KT, Bitterman KJ, Cohen, HY, Lamming, DW, Lavu, S, Wood JH, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA, “Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan,” Nature 2003 nov 11;425(6954): 191-6. Epub 2003 Aug 24
Promotes mitochondrial biogenesis (citations)
1. Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., et al. “Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α,” Cell, Vol 127, 1109-1122, December 15, 2006
2. Dasgupta, B., Milbrandt, J., “Resveratrol stimulates AMP kinase activity in neurons,” Proceedings of the National Academy of Sciences, Vol 104, no. 17, April 24, 2007
3. St-Pierre, J. Drori, S., Uldry, M., Silvaggi, J., Rhee, J., Jäger, S., Handschin, C., et al., “Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators,” Cell, Volume 127, 397-408, October 20, 2006
4. Civitarese, A., Carling, S., Heilbronn
5. Lopez-Lluch, G., Irusta, P., Navas, P., de Cabo, R., “Mitochondrial biogenesis and healthy aging,” Experimental Gerontology, Vol 43, 813-819, 2008
Slows AGE protein formation (citations)
1. Farrar, J., Hartle, D., Hargrove, J., Greenspan, P., “Inhibition of protein glycation by skins and seeds of the muscadinegrape” BioFactors, Vol 30, 193-200, 2007
2. Hudson
3. Bralley, E., Greenspan, P., Hargrove, J., Hartle, D., “Inhibition of Hyarluronidase Activity by Vitis rotundifolia (Muscadine) Berry Seeds and Skins, “ Pharmaceutical Biology, Vol 45, No. 9, pp 667-673, 2007
4. Ramasamy, R., Vannucci, S., Shi Du Yan, S., Herold, K., Yan, S., Schmidt, A., “Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation,” Glycobiology, vol. 15 no. 7 pp. 16R–28R, 2005
Guidance on Resveratrol Dosage and Safety (citations)
1. Reagan-Shaw, S., Nihal, M., Ahmad, N., “Dose translation from animal to human studies revisited” The FASEB Journal, fj.07-9574LSF, published online October 17, 2007
2. Baur, J., Pearson, K., Price, N., Jamieson, H., Lerin, C., Kalra, A., et al. “Resveratrol improves health and survival of mice on a high calorie diet,” Nature, Volume 444, November 16, 2006
3. Juan, M., Vinardell, M., Planas, J., “The Daily Oral Administration of High Doses of trans-Resveratrol to Rats for 28 Days is Not Harmful,” The Journal of Nutrition, 132: 257-260, 2002
4. Crowell, J., Korytko, P., Morrissey, R., Booth, M., Levine, B., “Resveratrol-Associated Renal Toxicity,” Toxicological Sciences, 82, 614-619, 2004
5. Boocock, D., Faust, G., Patel, K., Schinas, A., Brown, V., Ducharme, M., et al., “Phase 1 Does Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent,” Cancer Epidemiology Biomarkers & Prevention 2007, 16(6), June 2007
This is the independent study of resveratrol impact on disease and illnesses
CANCER
CARDIOVASCULAR
AGING
ALHEIZMER'S
BONE LOSS
PROTECTIVE
STROKE
ANTI VIRAL
PROSTATE
CATARACTS
HEARING LOSS
This is the independent study of resveratrol impact on disease and illnesses
CANCER
CARDIOVASCULAR
AGING
ALHEIZMER'S
BONE LOSS
PROTECTIVE
STROKE
ANTI VIRAL
PROSTATE
CATARACTS
HEARING LOSS
